The Punnett Square
One of the easiest ways to
calculate the mathematical probability of inheriting a specific trait was
invented by an early 20th century English geneticist named Reginald
Punnett. His technique employs what we now call a Punnett square. This is a
simple graphical way of discovering all the potential combinations of genotypes
that can occur in children. Punnett squares are standard tools used by genetic
counselors. The likelihood of inheriting many traits, including useful ones can
be predicted using them.
The letters inside the boxes
indicate probable genotypes (genetic makeup) of offspring resulting from the
cross of particular parents. There are 4 boxes and the genotypic results can be
written either as fractions or ratio.
If only one parent has single copy of a dominant allele for a dominant
disorder, their children will have 50% chance of inheriting the disorder and
50% of being entirely normal.